Potentiation of a Neuromuscular Blocking Agent Postoperatively by a Polypeptide Class Antibiotic: A Case Report
نویسنده
چکیده
Neuromuscular blocking agents (NMBAs) are administered as part of a general anesthetic to provide muscle relaxation during surgical procedures. Examples of commonly administered NMBAs are succinylcholine, rocuronium, vecuronium, and cisatracurium. Other medications administered during the surgical procedure may interact with NMBAs.1-12 For example, some antibiotics are known to potentiate the effects of NMBAs. Antibiotics are also commonly administered to surgical patients during the perioperative period as a prophylactic measure for postoperative surgical wound infections or are given intraoperatively as part of continued treatment or for a newly identified infection risk. Although most antibiotics work by altering the membrane permeability of bacterial cells, they can also affect the neuromuscular junction by causing neuromuscular blockade.1-13
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